Kristen Govoni

Associate Professor- Growth Physiology

Dr. Kristen GovoniContact

   Phone: (860) 486-2480

   Email: Kristen.Govoni@UConn.edu

   Office: ABL, Room 302A

   Lab: ABL, Room 317

   Lab Phone: (860) 486-8938

Dr. Govoni's Lab

Background

Education

  • Ph.D. (Animal Science), University of Connecticut, 2003
  • MS (Animal Science), University of Connecticut, 2002
  • BS (Animal Science), University of Connecticut, 1998

 
After receiving her Ph.D. in 2003, Dr. Govoni pursued postdoctoral research experience in the Musculoskeletal Disease Center at the Jerry L. Pettis VA Medical Center in Loma Linda, CA. In 2008, Dr. Govoni returned to her home state of CT and is currently an Associate Professor in the Department of Animal Science.

Academics

Classes Taught

ANSC 1602/ SAAS 202 Behavior and Training of Domestic Animals
ANSC 3313/ 5613 Growth Biology & Metabolism in Domestic Livestock/ Growth and Metabolism of Domestic Animals (Grad)
ANSC 3314W Scientifict Writing in Growth Biology & Metabolism in Domestic Livestock

Research Interests

  • Understanding growth and development at the cellular level to identify methods to improve animal health and efficiency of production
    • Determining the effects of poor maternal nutrition on pre- and post-natal development using a sheep model
    • Using a model of control, restricted, or over-feeding during gestation to identify the impacts on offspring growth (muscle, bone, and adipose tissue), metabolic dysregulation (liver, muscle, and blood)
    • Using omics approaches to identify the mechanisms of action through changes in mRNA expression, protein expression, metabolites, and epigenetic regulation based on the knowledge that poor maternal nutrition impairs offspring, growth, increases adipose deposition, and alters local and systemic metabolism.

Awards

  • Presidential M1 Mentorship Award, 2020
  • Petit Family Foundation Women in Science Leadership Award, Connecticut Science Center, 2019
  • Donald M. Kinsman Award For Excellence in CANR/RHSA Undergraduate Teaching by Junior Faculty, 2014
  • Northeast ASAS/ADSA Young Scientist Award For Research, 2013
  • Endocrine Society Travel Grant, 2006
  • ASBMR Young Investigator Award, 2005
  • Women in Endocrinology, Abstract Award, 2005
  • NACTA Teaching Award, 2003
  • ASAS/ADSA Northeast Graduate Student Paper Competition, Second Place, 2002

In the News

Recent Publications (Selected)

Kelly, MR, Halpern, A*, Reed, SA, Zinn, SA, and Govoni, KE# (2021) Understanding gestational and feed management practices of New England sheep producers. Transl Anim Sci. 2021 Jan 3;5(1):txaa234. doi: 10.1093/tas/txaa234

Gauvin, M*, Pillai, SM*, Reed, SA, Stevens, JR, Hoffman, ML*, Jones, AK, Zinn, SA, and Govoni, KE# (2020). Poor maternal nutrition during gestation in sheep alters prenatal muscle growth and development in offspring. J. Anim. Sci. 98: doi: 10.1093/jas/skz388.

Govoni, KE#, Reed, SA, and Zinn, SA. (2019). Invited Symposium Review: Poor maternal nutrition during gestation: Effects on offspring whole body and tissue-specific metabolism in livestock species. J Anim. Sci. 97:3142-3152. https://doi.org/10.1093/jas/skz157.

Martin, D, Jones, A, Pillai, S*, Hoffman, M*, McFadden, K**, Zinn, S, Govoni, K, and Reed, S# (2019). Maternal Restricted- and Over-Feeding During Gestation Result in Distinct Lipid and Amino Acid Metabolite Profiles in the Longissimus Muscle of the Offspring. Front. Physiol. https://doi.org/10.3389/fphys.2019.00515.

Duan, J, Flock, K, Jue, N, Zhang, M, Jones, A, Seesi, S, Mandoiu, II, Pillai, S*, Hoffman, M*, O'Neill, RJ, Zinn, S, Govoni, K, Reed, SA, Jiang, H, Jiang, Z, & Tian, X# (2019). Dosage Compensation and Gene Expression of the X Chromosome in Sheep. G3: Genes, Genomes, Genetics;9(1):305-314. doi: 10.1534/g3.118.200815.

Duan, JE, Zhang, M, Flock, K, Seesi, SA, Mandoiu, I, Jones, A, Johnson, E, Pillai, S*, Hoffman, M*, McFadden, K**, Jiang, H, Reed, S, Govoni, K, Zinn, S, Jiang, Z, Tian, XC# (2018). Effects of maternal nutrition on the expression of genomic imprinted genes in ovine fetuses. Epigenetics. 13(8):793-807. doi: 10.1080/15592294.2018.

Jones, AK, Gately, RE, Kellogg, TD, Zinn, SA, Govoni, KE, and Reed, SA# (2018). Evaluation of the Nova Vet Meter for sheep-side monitoring of β-hydroxybutyric acid (BHBA) and description of ewe BHBA during late gestation in three flocks from the Northeastern U.S. Res Vet Sci. May 7;118:491-497. doi: 10.1016/j.rvsc.2018.05.002.

Jones, AK, Hoffman, ML*, Pillai, SM*, McFadden**, KK, Govoni, KE, Zinn, SA, and Reed, SA# (2017). Gestational restricted- and over-feeding promote maternal and offspring inflammatory responses that are distinct and dependent on diet in sheep. Biol. Reprod. Dec 20. doi: 10.1093/biolre/iox174.

Zinn, SA#, Govoni, KE, and Vonnahme, KA. (2017). Developmental Programming: What Mom Eats Matters. Animal Frontiers 7:3-4.

Reed, SA and Govoni, KE#. 2017. How Mom’s diet affects offspring growth and health through modified stem cell function. Animal Frontiers 7:25-31 https://doi.org/10.2527/af.2017-0125.

Hoffman, ML*, Reed, SA, Pillai*, SM, Jones, AK, McFadden**, KK, Zinn, SA, and Govoni, KE# (2017). PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: The effects of poor maternal nutrition during gestation on offspring postnatal growth and metabolism. J. Anim. Sci. 95:2222-2232. doi: 10.2527/jas.2016.1229.

Jones, AK, Gately, RE, McFadden, KK**, Zinn, SA, Govoni, KE, and Reed, SA# (2017). Ultrasound during mid-gestation: Agreement with physical fetal and placental measurements and use in predicting gestational age in sheep. Reprod. Domest. Anim. 52:649-654. doi: 10.1111/rda.12961.

Pillai, SM*, Jones, AK, SM, Hoffman, ML*, McFadden, KK**, Reed, SA, Zinn, SA, and Govoni, KE# (2017). Fetal and organ development at gestational days 45, 90, 135 and at birth of lambs exposed to under- or over-nutrition during gestation. Transl. Anim. Sci. doi:10.2527/jas2016.0002.

Pillai, SM*, Sereda, NH**, Hoffman, ML*, Valley, EV**, Crenshaw, TD, Park, YK, Lee, JY, Zinn, SA, and Govoni, KE# (2016). Effects of poor maternal nutrition during gestation on bone development and mesenchymal stem cell activity in offspring. PLos One 11: doi: 10.1371/journal.pone.0168382.

Hoffman, ML*, Peck, KP, Wegrzyn, JL, Reed, SA, Zinn, SA, and Govoni, KE# (2016). Poor maternal nutrition during gestation alters the expression of genes involved in muscle development and metabolism in lambs. J. Anim. Sci. 94:3093-3099.

Hoffman, ML*, Peck, KN, Forella, ME, Fox, AR, Govoni, KE, and Zinn, SA# (2016). The effects of poor maternal nutrition during gestation on postnatal growth and development of lambs. J. Anim. Sci. 94:789-799. doi.org/10.2527/jas.2015-9933

Raja, JS, Hoffman, ML*, Govoni, KE, Zinn, SA, and Reed, SA# (2016). Restricted maternal nutrition alters myogenic regulatory factor expression in satellite cells of ovine offspring. Animal 10:1200-1203. doi: 10.1017/S1751731116000070.

Jones, AK, Gately, RE, McFadden**, KK, Zinn, SA, Govoni, KE, and Reed, SA# (2016). Transabdominal ultrasound for detection of pregnancy, fetal and placental landmarks, and fetal age before day 45 of gestation in the sheep. Theriogenology 85:939-945. doi: 10.1016/j.theriogenology.2015.11.002.

Govoni, KE# (2015). Use of mesenchymal stem cells in bone repair. J Anim Sci. Mar;93(3):871-878. doi: 10.2527/jas.2014-8516.

Harvey, B. M., Eschbach, M., Ackell, E., Kotha, S., Darre, M., Adamson, D., Ramanathan, R., Mancini, R., Govoni, KE. 2015. Effect of daily lithium chloride administration on bone quality and strength in growing broiler chickens. Poultry Science. Feb. 94. 296-301.

Reed, S. A., Raja, J. S., Hoffman, M. L., Zinn, S., Govoni, KE. 2014. Poor maternal nutrition inhibits muscle development in ovine offspring. Journal of Animal Science & Biotechnology. Sept. 1. 4.

Hoffman, ML, Rokossa, MA, Zinn, S, Hoagland, T, Govoni, KE. 2014. Poor maternal nutrition during gestation in sheep reduces circulating concentrations of insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3 in offspring. Dom Anim Endocr. Jul; 49, 39-48.

Hoffman, ML, McFadden, KK, Hoagland, T, Kazmer, G, Govoni, KE. 2014. Short communication: Expression of T-box 2 and 3 in the bovine mammary gland. J Dairy Sci. Jul; 97(7):4322-8. doi: 10.3168/jds.2013-7771.

Glynn, E, Alfredo, S-L, Zinn, S, Hoagland, T, Govoni, KE. 2013. Culture conditions for equine bone marrow mesenchymal stem cells and expression of key transcription factors during their differentiation into osteoblasts. J Anim Sci Biotechnology. Oct 29; 4(1): 40. doi: 10.1186/2049-1891-4-40.

Xing W, Govoni KE, Donahue LR, Kesavan C, Wergedal J, Long C, Bassett JH, Gogakos A, Wojcicka A, Williams GR, Mohan S. 2012. Genetic evidence that thyroid hormone is indispensable for prepubertal insulin-like growth factor-I expression and bone acquisition in mice.  J Bone Miner Res. 2012 May;27(5):1067-79.

Govoni, KE.  2012. Insulin-like growth factor-I molecular pathways in osteoblasts: Potential targets for pharmacological manipulation.  Curr Mol Pharmacol. 2012 Jun 1;5(2):143-52.

Ackell, ER, Sanchez-Londono, A, Zinn, SA, Hoagland, TA, and Govoni, KE. 2012.  Culture conditions for equine bone marrow mesenchymal stem cells and expression of key transcription factors during their differentiation into osteoblasts. Equine Veterinary Journal.  Accepted with revisions

Govoni, KE, Goodman, D, Maclure RM, Penfold, LM, and Zinn, SA. 2011.  Serum concentrations of insulin-like growth factor and insulin-like growth factor binding protein-2 and -3 in eight hoofstock species. Zoo Biol. 30:275-84.

Govoni, KE, Linares, GR, Chen, ST, Pourteymoor, S, and Mohan, S. 2009. T-box 3 negatively regulates osteoblast differentiation by inhibiting expression of osterix and runx2. J Cell Biochem. 106:482-90.

Linares, GR, Xing, W, Govoni, KE, Chen, ST, and Mohan, S. 2009. Glutaredoxin 5 regulates osteoblast apoptosis by protecting against oxidative stress. Bone. 44:795-804.

Govoni, KE, Donahue LR, Marden C, Mohan S. 2008. Complex genetic regulation of bone mineral density and insulin-like growth factor-I in C57BL/6J-Chr #A/J/NaJ chromosome substitution strains. Physiol Genomics. 35:159-64. Epub 2008 Aug 5.

Govoni, KE, Wergedal, JE, Chadwick, RB, Srivistava, AK, and Mohan, S. 2008. Pre-pubertal OVX increases IGF-I expression and bone accretion in C57BL/6J mice. Am J Physiol Endocrinol Metab. 295:E1172-80. Epub 2008 Sep 23.

Govoni, KE, Wergedal, JE, Florin, L, Angel P, Baylink, DJ, and Mohan, S. 2007. Conditional Deletion of IGF-I in Collagen Type 1 alpha-2 (Col1 alpha-2) Expressing Cells Results In Postnatal Lethality and a Dramatic Reduction in Bone Accretion. Endocrinology 148:8706-15 Epub 2007 Aug 23.

Velayudhan, BT, Govoni, KE, Hoagland, TA, and Zinn, SA. 2007. Growth rate and concentrations of the somatotropic axis in beef cattle administered exogenous bovine somatotropin beginning at 200, 250 and 300 days of age. J. Anim. Sci. 85:2886-72.

Govoni, KE, Lee, SK, Chung, YS, Behringer, RR, Wergedal, JE, Baylink, DJ, and Mohan, S. 2007. Disruption of insulin-like growth factor (IGF)-I expression in type II?I collagen expressing cells reduces bone length and width in mice. Physiol. Genomics. 30:354-62 Epub 2007May 22.

Govoni, KE, Baylink, DJ, Chen, J, and Mohan, S. 2006. Disruption of four and a half LIM domain (FHL)-2 decreases bone mineral content and bone mineral density in femur and tibia bones of female mice. Calcified Tissue International 79:112-7. Epub 2006 Aug 15.

Govoni, KE, Lee, SK, Chadwick, RB, Yu, H, Kasukawa, Y, Baylink, DJ, and Mohan, S. 2006. Whole Genome Microarray Analysis of the In Vivo Effects of a Single Effective GH Dose on Gene Expression in Bones of GH-Deficient lit/lit Mice: GH regulates T-box3, a Novel Transcription Factor, Independent of IGF-I. Am. J. Physiol. Endocrinol. Metab. 291:E128-36. Epub 2006 Feb 7.

Govoni, KE, Kramer, A, Winter, E, Amaar, YG, Baylink, DJ, and Mohan, S. 2005 In Press. Regulation of insulin-like growth factor binding protein (IGFBP)-5, four and a half lim (FHL)-2, and a disintegrin and metalloprotease (ADAM)-9 expression in osteoblasts. Growth Hormone and IGF Research 16:49-56. Epub 2005 Nov 28.

Govoni, KE, Baylink, DJ, and Mohan, S. 2005. The multi-functional role of insulin-like growth factor binding proteins in bone. Pediatr. Nephrol. 20:261-268.

Govoni, KE, Hoagland, TA, and Zinn, SA. 2004. The ontogeny of the somatotropic axis in Hereford calves from birth to one year of age and its response to administration of exogenous bovine somatotropin. J. Anim. Sci. 82:1646-1655.

Govoni, KE, Hoagland, TA, and Zinn, SA. 2003. The ontogeny of the somatotropic axis in male and female Hereford calves from birth to one year of age. J. Anim. Sci. 81:2811-2817.

Govoni, KE, XC Tian, GW Kazmer, M Taneja, B Enright, AL Rivard, X Yang and SA Zinn. 2002. Age-related changes of the somatotropic axis in cloned Holstein calves. Biol. of Reprod. 66:1293-1298.

Rausch, MI, MW Tripp, KE Govoni, W Zang, WJ Weber, BA Crooker, TA Hoagland and SA Zinn. 2002. Limit feeding and somatotropin supplementation in growing beef cattle. J. Anim. Sci. 80:94-100.

Phillips, AL, C Faustman, MP Lynch, KE Govoni, TA Hoagland and SA Zinn. 2001. Effects of dietary alpha-tocopherol supplementation on color and lipid stability in pork. Meat Science 58:389-393.

Freake, HC, KE Govoni, K Guda, C Huang and SA Zinn. 2001. Actions and interactions of thyroid hormones and zinc status in growing rats. J. Nutr. 131:1135-1141.

Hobbies/Non-Academic Interests

  • Horseback riding
  • Camping
  • Hiking
  • Running 

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