Young Tang

Associate Professor in Animal Science

Contact

   Phone: 860-486-6619

   Email: Yong.Tang@UConn.edu

   Office: ABL 320B

   Lab: ABL 332
                                                                                                                                                  

• Ph.D. (Animal Science), University of Connecticut, Storrs, CT, 2012
• Research Investigator, Millennium Pharmaceuticals, Inc., Cambridge, MA, 2004
• Sr. Research Associate, Millennium Pharmaceuticals, Inc. Cambridge, MA, 2002
• Research Associate, University of Central Florida, Orlando, FL, 1999
• Guest Scientist, University of Erlangen-Nurnberg, Germany, 1997
• M.S. (Medical Genetics), Hunan Medical University, P.R. China, 1996
• Bachelor of Medicine (5-Year Program Including 1-Year Clinical Internship), Hunan Medical University, P.R. China, 1993

Academics

Classes Taught

ANSC 5619	Signaling Pathways
ANSC 5694	Animal Science Seminar

 

Research Interests

• Generation of completely reprogrammed induced pluripotent stem cells of domestic animals
• Understanding epigenetic and signaling pathways controlling somatic cell reprogramming, stem cell maintenance, and differentiation processes
• Study of viral pathogenic pathways to improve the animal health and reproduction, as well as the treatment of human diseases

Awards and Achievements

• PITCH Promising Project Award, 2018
• Atomwise Award, 2017 - Learn more about this award here.
• USDA/NIFA Fellowship Award, 2013
• Excellence in Graduate Research Award, UCONN, 2011
• Doctoral Dissertation Fellowship Award, UCONN, 2011
• Xiangzhong (Jerry) Yang Graduate Research Excellence Award, UCONN, 2011
• Employee Star Award, Millennium Pharmaceuticals, Inc., 2004
• Employee Star Award, Millennium Pharmaceuticals, Inc., 2003

Current Positions of Former Graduate Students

Dr. Ling Wang: Research Associate, Peking University, China

Dr. Delun Huang: Faculty member, Guangxi University of Chinese Medicine, China
 
Dr. Chang Huang: Postdoc, Laboratory of Retrovirus Research, CBER, FDA, Maryland
 

In the News

• UConn Scientist Battles Costly Pig Virus with AI-Inspired Compound
• UConn Researchers Identify Compound Successful in Blocking Virus Devastating Global Pig Populations
• Researchers Aim to Identify Potential New Drugs for Wide Range of Diseases Using AI
• Programming of Bovine Stem Cells from Adult Cells May Help Improve Human and Animal Health
• Protein Engineering Of Reprogramming Factors: A Strategy To Facilitate The Production Of Patient-Specific Stem Cells
• Atomwise Expands its Groundbreaking Artificial Intelligence Screening Program to Support Academic Projects Worldwide

Publications

Su, Y., Zhu, J., Salman, S., Tang, Y. (2020). The Induced Pluripotent Stem Cells from Farm Animals. Journal of Animal Science. In Press. https://doi.org/10.1093/jas/skaa343.

Huang, C, Zhu, J, Wang, L, Chu, A, Yin, Y, Vali, K, Garmendia, A., Tang, Y. (2020). Cryptotanshinone Protects Porcine Alveolar Macrophages from Infection with Porcine Reproductive and Respiratory Syndrome Virus. Antiviral Research. https://doi.org/10.1016/j.antiviral.2020.104937

Huang, C., Bernard, D., Zhu, J., Dash, RC., Chu, A., Knupp, A., Hakey, A., Hadden, MK., Garmendia, A., & Tang, Y. 2020. Small Molecules Block Porcine Reproductive and Respiratory Syndrome Virus Interaction with CD163 and Infection of Pig Cells. BMC Virology Journal. DOI: 10.1186/s12985-020-01361-7. 

Wang, L., Su, Y., Huang, C., Yin, Y., Zhu, J., Knupp, A., Chu, A., Tang, Y., 2019. FOXH1 Is Regulated by NANOG and LIN28 for Early-stage Reprogramming. Scientific Reposts 9:16443 | https://doi.org/10.1038/s41598-019-52861-8.

Wang, L., Su, Y., Huang, C., Yin, Y., Chu, A., Knupp, A., Tang, Y., 2019. NANOG and LIN28 Dramatically Improve Human Cell Reprogramming by Modulating LIN41 and Canonical WNT Activities. Biol Open In Press.

Huang D, Wang L, Talbot NC, Huang C, Pu L, Zhao X, Tian X, Zhang M, Tang Y.  Analyzing bovine OCT4 and NANOG enhancer activity in pluripotent stem cells using fluorescent protein reporters. PLoS ONE. 2018 Oct 5;13(10):e0203923. doi: 10.1371/journal.pone.0203923. eCollection 2018.

Wang L., Jiang Z., Huang D., Duan J., Huang C., Sullivan S., Vali K., Yin Y., Zhang M., Wegrzyn J., Tian X., Tang Y. JAK/STAT3 regulated global gene expression dynamics during late-stage reprogramming process. BMC Genomics. 2018. https://doi.org/10.1186/s12864-018-4507-2.

Huang D., Wang L., Duan J., Huang C., Tian X., Zhang M., Tang Y. LIF activated Jak signaling determines Esrrb expression during late stage reprogramming. Biology Open 2017 : bio.029264 doi: 10.1242/bio.029264.

Wang, L., Huang, DL., Huang, C., Yin, YX., Vali, K., Zhang, M., Tang, Y. Enhanced human somatic cell reprogramming efficiency by fusion of the MYC transactivation domain and OCT4. Stem Cell Research. 2017. doi: https://doi.org/10.1016/j.scr.2017.10.014.

Wang L, Huang D, Jiang Z, Luo Y, Norris C, Zhang M, Tian X, Tang Y. pii: bio.024505. doi: 10.1242/bio.024505. Akt3 is responsible for the survival and proliferation of embryonic stem cells. Biol Open. May 8, 2017. Epub ahead of print.

Talbot, N. C., Wang, L., Garrett, W. M., Caperna, T. J., Tang, Y. (2016). Establishment and characterization of feeder cell-dependent bovine fetal liver cell lines. 52. (3), 314-26. In vitro cellular & developmental biology. Animal.

Jiang, Z., Tang Y., Zhao, X., Zhang, M., Blomberg, L., Tian, X. Knockdown of Brm and Baf170, Components of Chromatin Remodeling Complex, Facilitates Reprogramming of Somatic Cells. Stem Cell and Development. May 2015. Ahead of Print.

Lin, C.-J., Amano, T., Tang Y., Tian, X. (2014). Improved derivation efficiency and pluripotency of stem cells from the refractory inbred C57BL/6 mouse strain by small molecules. PLoS ONE(9 ed.), e106916. September 11, 2014.

Jiang, Z., Sun, J., Dong, H., Luo, O., Zheng, X., Obergfell, C. J., Tang Y., Bi, J., O'Neill, R. J., Ruan, Y., Chen, J., Tian, X. (2014). Transcriptional profiles of bovine in vivo pre-implantation development. BMC genomics, vol. 15, 756. September 4, 2014.

Tang Y, Jiang Z, Luo Y, Zhao X, Wang L, Norris C, Tian XC. (2014). Differential Effects of Akt Isoforms on Somatic Cell Reprogramming. J. Cell Sci. Jul 18. pii: jcs.150029. [Epub ahead of print]

Yuan Y, Su M, Song Y, Tang Y, Tian XC, Rood D and Lai L. (2014). Tbx1 Modulates Endodermal and Mesodermal Differentiation from Mouse Induced Pluripotent Stem cells. Stem Cells Dev. 23(13):1491-500.

Tang Y and Tian XC. (2013). Jak/Stat3 and Somatic Cell Reprogramming. JAK-STAT. 2:e24935; http://dx.doi.org/10.4161/jkst.24935 (Invited Review).

Tang Y, Luo Y, Jiang Z, Ma Y, Lin CJ, Kim C, Carter MG, Amano T, Park J, Kish S, and Tian XC. (2012). Jak/Stat3 Signaling Promotes Complete Reprogramming by Epigenetic Regulation. Stem Cells. doi: 10.1002/stem.1225.

Tang Y, Lin CJ, and Tian XC. (2011). Functionality and Transduction Condition Evaluation of Recombinant Klf4 for Improved Reprogramming of iPS Cells. Cellular Reprogram. 13(2):99-112.

Park J, Kim C, Tang Y, Amano A, Lin CJ and Tian XC. (2011). Reprogramming of Mouse Fibroblasts to An Intermediate State of Differentiation by Chemical Induction. Cellular Reprogram. 13(2):121-31.

Fernandez-Valle C, Tang Y, Richard J, Rodenas-Ruano A, Taylor A, Hackler E, Biggerstaff J & Lacovelli J. (2002). Paxillin Binds Schwannomin and Regulates Its Density-Dependent Localization and Effect on Cell Morphology. Nature Genetics. 31(4):354-62.

Schmucker B, Tang Y and Kressel M. (1999). Novel Alternatively Spliced Isoforms of the Neurofibromatosis Type 2 Tumor Suppressor Are Targeted to the Nucleus and Cytoplasmic Granules. Hum. Mol. Genet. 8(8): 1561-70.

Tang Y, Xia JH, Zhou JN, Li HJ, Wang DP, Dai HP, Long ZG, Tang BS, Huang L and Deng HX. (1998). Localization of the Gene for 4 Hereditary Multiple Exostoses Families. I Chuan Hsueh Pao. (ACTA Genetica Sinica). 25(1): 1-7.

Hobbies/ Non-Academic Interests

• Traveling

• Reading