Sarah A. Reed

Associate Professor- Muscle Biology & Equine Science

Contact

Phone: (860) 486-8452

Email: Sarah.Reed@UConn.edu

Office: George White Bldg., Room 203

Lab: George White Bldg., Room 206

Lab Phone: (860) 486-8457

 

Dr. Reed's Lab

Fetal Programming Research Group

Background

Education

  • Ph.D. (Animal Molecular and Cellular Biology), University of Florida, 2009
  • MD (Animal Science), University of Florida, 2006
  • B.S. (Equine Science), Delaware Valley College, 2003

 
Dr. Reed pursued post doctoral training in muscle biology in the Department of Physical Therapy at the University of Florida and joined the faculty of the Department of Animal Science at UConn in 2011.

Academics

Area of Interest

The focus of my current research is understanding how poor materinal diet during gestation alters offspring muscle development and pre- and post-natal muscle growth.  Specifically, we are interested in how over- and restricted-feeding alter the metabolism of the muscle and whole animal, the function of the muscle stem cells (satellite cells), and the muscle environment, including oxidative and inflammatory status.

An additional interest of my lab is the characterization of muscle satellite cells in horses. The horse is an athletic animal and thus undergoes significant musculoskeletal remodeling during training and detraining periods. Understanding the role of the satellite cell in equine muscle will allow comparisons between species as well as a better understanding of how equine muscle adapts to each condition.

Classes Taught

ANSC 3311  Comparative Exercise Physiology
ANSC 3312W  Scientific Writing in Comparative Exercise Physiology
ANSC 3452/ SAAS 252  Horse Breeding Farm Management
ANSC 3457 Advanced Broodmare and Foal Management
ANSC 4697W Undergraduate Honors Thesis Writing in Animal Science
ANSC 5615  Comparative Exercise Physiology
ANSC 5683 Graduate Teaching Experience

Awards and Acheivements

  • 2017 UCAHNRA Excellence in Teaching award
  • 2015 CAHNR Donald M. Kinsman Award for Excellence in Teaching
  • 2014 Northeast ASAS/ADSA Young Teacher Award

Publications

Martin D.E., A.K. Jones, S.M. Pillai, M.L. Hoffman, K.K. McFadden, S.A. Zinn, K.E. Govoni, and S.A. Reed. Maternal restricted- and over-feeding during gestation result in distinct lipid and amino acid metabolite profiles in the longissimus muscle of the offspring. Front Physiol. 2019. 10:515. doi: 10.3389/fphys.2019.00515

 

Govoni K.E., S.A. Reed, and S.A. Zinn. Poor maternal nutrition during gestation: Effects on offspring whole body and tissue-specific metabolism in livestock species. J Anim Sci. 2019. pii: skz157. doi: 10.1093/jas/skz157

 

Jones, A.K., R.E. Gately, T.D. Kellogg, S.A. Zinn, K.E. Govoni, and S.A. Reed. Evaluation of the Nova Vet Meter for sheep-side monitoring of beta-hydroxybutyric acid (BHBA) and description of ewe BHBA during late gestation in three flocks from the Northeastern U.S. Res Vet Sci. 2018. doi:10.1016.j.rvsc.2018.05.002
 

Jones, A.K., M.L. Hoffman, S.M. Pillai, K.K. McFadden, K.E. Govoni, S.A. Zinn, and S.A. Reed. Gestational restricted- and over-feeding promote maternal and offspring inflammatory responses that are distinct and dependent on diet in sheep. Biol Reprod. 2018. 98:184-196.  doi:10.1093/biolre/iox174

Jones, A. K., & Reed, S. A. (2017). Benefits of ultrasound scanning during gestation in the small ruminant. 149, 163-171. 10.1016/j.smallrumres.2017.02.008

Pillai, S. M., Jones, A. K., Hoffman, M. L., McFadden, K. K., Reed, S. A., Zinn, S., & Govoni, K. (2017). Fetal and organ development at gestational days 45, 90, 135 and at birth of lambs exposed to under- or over-nutrition during gestation. 1, 16-25. 10.2527/tas2016.0002

Hoffman, M. L., Reed, S. A., Pillai, S. M., Jones, A. K., McFadden, K. K., Zinn, S., & Govoni, K. (2017). The effects of poor maternal nutrition during gestation on offspring postnatal growth and metabolism. 94, 3093-3099. 10.2527/jas.2016-1229

Jones, A. K., Gately, R. E., McFadden, K. K., Hoffman, M. L., Pillai, S. M., Zinn, S., Govoni, K., & Reed, S. A. (2017). Ultrasound during mid-gestation: Agreement with physical foetal and placental measurements and use in predicting gestational age in sheep. 10.1111/rda.12961

Hoffman, M. L., Peck, K. N., Wegrzyn, J., Reed, S. A., Zinn, S., & Govoni, K. (2016). Poor maternal nutrition during gestation alters the expression of genes i

nvolved in muscle development and metabolism in lambs. 94(7), 3093-9. 10.2527/jas.2016-0570

Raja JS, Hoffman ML, Govoni KE, Zinn SA, Reed SA. Restricted maternal nutrition alters myogenic regulatory factor expression in satellite cells of ovine offspring. Animal. 2016 Feb 9:1-4.

Jones AK, Gately RE, McFadden KK, Zinn SA, Govoni KE, Reed SA. Transabdominal ultrasound for detection of pregnancy, fetal and placental landmarks, and fetal age before Day 45 of gestation in the sheep. Theriogenology. 2016 Mar 15;85(5):939-45.e1. doi: 10.1016/j.theriogenology.2015.11.002.

LaVigne EK, Jones AK, Londoño AS, Schauer AS, Patterson DF, Nadeau JA, Reed SA. Muscle growth in young horses: Effects of age, cytokines, and growth factors. J Anim Sci. 2015 Dec;93(12):5672-80. doi: 10.2527/jas.2015-9634.

Reed SA. SafeAssign as a tool for student identification of potential plagiarism. Natural Sciences Education. 2015 July; 44:95-100

Reed SA, LaVigne EK, Jones AK, Patterson DF, Schauer AL. HORSE SPECIES SYMPOSIUM: The aging horse: Effects of inflammation on muscle satellite cells. J Anim Sci. 2015 Mar;93(3):862-70.

Reed SA, Johnson SE. Expression of scleraxis and tenascin C in equine adipose and umbilical cord blood derived stem cells is dependent upon substrata and FGF supplementation. Cytotechnology. 2014 Jan;66(1):27-35. doi: 10.1007/s10616-012-9533-3. Epub 2013 Jan 9.
Reed SA, Raja JS, Hoffman ML, Zinn SA, Govoni KE. Poor maternal nutrition inhibits muscle development in ovine offspring. J Anim Sci Biotechnol. 2014 Sep 5;5(1):43. doi: 10.1186/2049-1891-5-43.

Reed SA, Leahy ER. Growth and Development Symposium: Stem cell therapy in equine tendon injury. J Anim Sci. 2013 Jan;91(1):59-65. doi: 10.2527/jas.2012-5736. Epub 2012 Oct 16. Invited Review.

Reed SA, Johnson SE. Refinement of culture conditions for maintenance of undifferentiated equine umbilical cord blood stem cells. Journal of equine veterinary science. 2012 June; 32(6):360-366.

Reed SA, Sandesara PB, Senf SM, Judge AR. Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy. FASEB J. 2012 Mar;26(3):987-1000. doi: 10.1096/fj.11-189977. Epub 2011 Nov 18.

Senf SM, Sandesara PB, Reed SA, Judge AR. p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle. Am J Physiol Cell Physiol. 2011 Jun;300(6):C1490-501. doi: 10.1152/ajpcell.00255.2010. Epub 2011 Mar 9.

Reed SA, Senf SM, Cornwell EW, Kandarian SC, Judge AR. Inhibition of IkappaB kinase alpha (IKKα) or IKKbeta (IKKβ) plus forkhead box O (Foxo) abolishes skeletal muscle atrophy. Biochem Biophys Res Commun. 2011 Feb 18;405(3):491-6. doi: 10.1016/j.bbrc.2011.01.059.

Li J, Reed SA, Johnson SE. Hepatocyte growth factor (HGF) signals through SHP2 to regulate primary mouse myoblast proliferation. Exp Cell Res. 2009 Aug 1;315(13):2284-92. doi: 10.1016/j.yexcr.2009.04.011.

Reed SA, Johnson SE. Equine umbilical cord blood contains a population of stem cells that express Oct4 and differentiate into mesodermal and endodermal cell types. J Cell Physiol. 2008 May;215(2):329-36.

Reed SA, Ouellette SE, Liu X, Allen RE, Johnson SE. E2F5 and LEK1 translocation to the nucleus is an early event demarcating myoblast quiescence. J Cell Biochem. 2007 Aug 15;101(6):1394-408.
 

Hobbies/ Non-Academic Interests

  • Photography
  • Dogs
  • Horseback Riding

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Department of Animal Science
Unit 4040
17 Manter Road
Storrs, CT 06269-4040

George White Building Room 107
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Phone: (860) 486-2413
Fax: (860) 486-4375
Email: AnimalScience@UConn.edu