Sarah A. Reed
Assistant Professor, Equine
Phone: (860) 486-8452
Office: George White Bldg., Room 203
Lab: George White Bldg., Room 206
Lab Phone: (860) 486-8457
- Ph.D. (Animal Molecular and Cellular Biology), University of Florida, 2009
- MD (Animal Science), University of Florida, 2006
- B.S. (Equine Science), Delaware Valley College, 2003
Dr. Reed pursued post doctoral training in muscle biology in the Department of Physical Therapy at the University of Florida and joined the faculty of the Department of Animal Science at UConn in 2011.
Area of Interest
The focus of my current research is the role of muscle satellite cells (stem cells) during growth and disease conditions. Severe muscle atrophy occurs during diseases such as cancer, diabetes and chronic heart failure, resulting in muscle weakness and poor patient prognosis. During this time, satellite cells are activated but muscle regeneration is inhibited, although this process is poorly understood. My lab seeks to understand the mechanisms by which satellite cells are activated yet their regenerative capacity is suppressed during this time. In vitro and in vivo models are used to study these changes.
An additional interest of my lab is the characterization of muscle satellite cells in horses. The horse is an athletic animal and thus undergoes significant musculoskeletal remodeling during training and detraining periods. Understanding the role of the satellite cell in equine muscle will allow comparisons between species as well as a better understanding of how equine muscle adapts to each condition.
|| Comparative Exercise Physiology
|| Scientific Writing in Comparative Exercise Physiology
|ANSC 3452/ SAAS 252
|| Horse Breeding Farm Management
||Undergraduate Honors Thesis Writing in Animal Science
|| Comparative Exercise Physiology
||Graduate Teaching Experience
Jones, A. K., & Reed, S. A. (2017). Benefits of ultrasound scanning during gestation in the small ruminant. 149, 163-171. 10.1016/j.smallrumres.2017.02.008
Pillai, S. M., Jones, A. K., Hoffman, M. L., McFadden, K. K., Reed, S. A., Zinn, S., & Govoni, K. (2017). Fetal and organ development at gestational days 45, 90, 135 and at birth of lambs exposed to under- or over-nutrition during gestation. 1, 16-25. 10.2527/tas2016.0002
Hoffman, M. L., Reed, S. A., Pillai, S. M., Jones, A. K., McFadden, K. K., Zinn, S., & Govoni, K. (2017). The effects of poor maternal nutrition during gestation on offspring postnatal growth and metabolism. 94, 3093-3099. 10.2527/jas.2016-1229
Jones, A. K., Gately, R. E., McFadden, K. K., Hoffman, M. L., Pillai, S. M., Zinn, S., Govoni, K., & Reed, S. A. (2017). Ultrasound during mid-gestation: Agreement with physical foetal and placental measurements and use in predicting gestational age in sheep. 10.1111/rda.12961
Hoffman, M. L., Peck, K. N., Wegrzyn, J., Reed, S. A., Zinn, S., & Govoni, K. (2016). Poor maternal nutrition during gestation alters the expression of genes involved in muscle development and metabolism in lambs. 94(7), 3093-9. 10.2527/jas.2016-0570
Raja JS, Hoffman ML, Govoni KE, Zinn SA, Reed SA. Restricted maternal nutrition alters myogenic regulatory factor expression in satellite cells of ovine offspring. Animal. 2016 Feb 9:1-4.
Jones AK, Gately RE, McFadden KK, Zinn SA, Govoni KE, Reed SA. Transabdominal ultrasound for detection of pregnancy, fetal and placental landmarks, and fetal age before Day 45 of gestation in the sheep. Theriogenology. 2016 Mar 15;85(5):939-45.e1. doi: 10.1016/j.theriogenology.2015.11.002.
LaVigne EK, Jones AK, Londoño AS, Schauer AS, Patterson DF, Nadeau JA, Reed SA. Muscle growth in young horses: Effects of age, cytokines, and growth factors. J Anim Sci. 2015 Dec;93(12):5672-80. doi: 10.2527/jas.2015-9634.
Reed SA. SafeAssign as a tool for student identification of potential plagiarism. Natural Sciences Education. 2015 July; 44:95-100
Reed SA, LaVigne EK, Jones AK, Patterson DF, Schauer AL. HORSE SPECIES SYMPOSIUM: The aging horse: Effects of inflammation on muscle satellite cells. J Anim Sci. 2015 Mar;93(3):862-70.
Reed SA, Johnson SE. Expression of scleraxis and tenascin C in equine adipose and umbilical cord blood derived stem cells is dependent upon substrata and FGF supplementation. Cytotechnology. 2014 Jan;66(1):27-35. doi: 10.1007/s10616-012-9533-3. Epub 2013 Jan 9.
Reed SA, Raja JS, Hoffman ML, Zinn SA, Govoni KE. Poor maternal nutrition inhibits muscle development in ovine offspring. J Anim Sci Biotechnol. 2014 Sep 5;5(1):43. doi: 10.1186/2049-1891-5-43.
Reed SA, Leahy ER. Growth and Development Symposium: Stem cell therapy in equine tendon injury. J Anim Sci. 2013 Jan;91(1):59-65. doi: 10.2527/jas.2012-5736. Epub 2012 Oct 16. Invited Review.
Reed SA, Johnson SE. Refinement of culture conditions for maintenance of undifferentiated equine umbilical cord blood stem cells. Journal of equine veterinary science. 2012 June; 32(6):360-366.
Reed SA, Sandesara PB, Senf SM, Judge AR. Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy. FASEB J. 2012 Mar;26(3):987-1000. doi: 10.1096/fj.11-189977. Epub 2011 Nov 18.
Senf SM, Sandesara PB, Reed SA, Judge AR. p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle. Am J Physiol Cell Physiol. 2011 Jun;300(6):C1490-501. doi: 10.1152/ajpcell.00255.2010. Epub 2011 Mar 9.
Reed SA, Senf SM, Cornwell EW, Kandarian SC, Judge AR. Inhibition of IkappaB kinase alpha (IKKα) or IKKbeta (IKKβ) plus forkhead box O (Foxo) abolishes skeletal muscle atrophy. Biochem Biophys Res Commun. 2011 Feb 18;405(3):491-6. doi: 10.1016/j.bbrc.2011.01.059.
Li J, Reed SA, Johnson SE. Hepatocyte growth factor (HGF) signals through SHP2 to regulate primary mouse myoblast proliferation. Exp Cell Res. 2009 Aug 1;315(13):2284-92. doi: 10.1016/j.yexcr.2009.04.011.
Reed SA, Johnson SE. Equine umbilical cord blood contains a population of stem cells that express Oct4 and differentiate into mesodermal and endodermal cell types. J Cell Physiol. 2008 May;215(2):329-36.
Reed SA, Ouellette SE, Liu X, Allen RE, Johnson SE. E2F5 and LEK1 translocation to the nucleus is an early event demarcating myoblast quiescence. J Cell Biochem. 2007 Aug 15;101(6):1394-408.
Awards and Acheivements
- 2017 UCAHNRA Excellence in Teaching award
- 2015 CAHNR Donald M. Kinsman Award for Excellence in Teaching
- 2014 Northeast ASAS/ADSA Young Teacher Award
Hobbies/ Non-Academic Interests
- Horseback Riding