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sarah A. reed, assistant professor, equine
Dr. Reed's lab is currently seeking an MS or PhD graduate student. Please click here for more information.
Dr. Reed pursued post doctoral training in muscle biology in the Department of Physical Therapy at the University of Florida and joined the faculty of the Department of Animal Science at UConn in 2011.
Area of Interest
The research focus in the Reed Lab is understanding how muscle satellite cells (stem cells) respond to various environmental and physiological conditions. Specifically, we are interested in how poor maternal nutrition during gestation alters muscle development and satellite cell function and metabolism in the offspring. In addition, my lab seeks to understand how disease conditions, in particular, cancer cachexia, alter satellite cell function. An additional interest of my lab is the characterization of muscle satellite cells in horses. The horse is an athletic animal and thus undergoes significant musculoskeletal remodeling during training and detraining periods. Understanding the role of the satellite cell in equine muscle will allow comparisons between species as well as a better understanding of how equine muscle adapts to each condition.
Hoffman, M. L., Peck, K. N., Wegrzyn, J., Reed, S. A., Zinn, S., Govoni, K. Poor maternal nutrition during gestation alters the expression of genes involved in muscle development and metabolism in lambs. J Anim Sci. 2016. In Press. doi: 10.2527/jas.2016-0570
Raja JS, Hoffman ML, Govoni KE, Zinn SA, Reed SA. Restricted maternal nutrition alters myogenic regulatory factor expression in satellite cells of ovine offspring. Animal. 2016 Feb 9:1-4.
Jones AK, Gately RE, McFadden KK, Zinn SA, Govoni KE, Reed SA. Transabdominal ultrasound for detection of pregnancy, fetal and placental landmarks, and fetal age before Day 45 of gestation in the sheep. Theriogenology. 2016 Mar 15;85(5):939-45.e1. doi: 10.1016/j.theriogenology.2015.11.002.
LaVigne EK, Jones AK, Londoño AS, Schauer AS, Patterson DF, Nadeau JA, Reed SA. Muscle growth in young horses: Effects of age, cytokines, and growth factors. J Anim Sci. 2015 Dec;93(12):5672-80. doi: 10.2527/jas.2015-9634.
Reed SA. SafeAssign as a tool for student identification of potential plagiarism. Natural Sciences Education. 2015 July; 44:95-100.
Reed SA, LaVigne EK, Jones AK, Patterson DF, Schauer AL. HORSE SPECIES SYMPOSIUM: The aging horse: Effects of inflammation on muscle satellite cells. J Anim Sci. 2015 Mar;93(3):862-70.
Reed SA, Johnson SE. Expression of scleraxis and tenascin C in equine adipose and umbilical cord blood derived stem cells is dependent upon substrata and FGF supplementation. Cytotechnology. 2014 Jan;66(1):27-35. doi: 10.1007/s10616-012-9533-3. Epub 2013 Jan 9.
Reed SA, Raja JS, Hoffman ML, Zinn SA, Govoni KE. Poor maternal nutrition inhibits muscle development in ovine offspring. J Anim Sci Biotechnol. 2014 Sep 5;5(1):43. doi: 10.1186/2049-1891-5-43.
Reed SA, Leahy ER. Growth and Development Symposium: Stem cell therapy in equine tendon injury. J Anim Sci. 2013 Jan;91(1):59-65. doi: 10.2527/jas.2012-5736. Epub 2012 Oct 16. Invited Review.
Reed SA, Johnson SE. Refinement of culture conditions for maintenance of undifferentiated equine umbilical cord blood stem cells. Journal of equine veterinary science. 2012 June; 32(6):360-366.
Reed SA, Sandesara PB, Senf SM, Judge AR. Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy. FASEB J. 2012 Mar;26(3):987-1000. doi: 10.1096/fj.11-189977. Epub 2011 Nov 18.
Senf SM, Sandesara PB, Reed SA, Judge AR. p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle. Am J Physiol Cell Physiol. 2011 Jun;300(6):C1490-501. doi: 10.1152/ajpcell.00255.2010. Epub 2011 Mar 9.
Reed SA, Senf SM, Cornwell EW, Kandarian SC, Judge AR. Inhibition of IkappaB kinase alpha (IKKα) or IKKbeta (IKKβ) plus forkhead box O (Foxo) abolishes skeletal muscle atrophy. Biochem Biophys Res Commun. 2011 Feb 18;405(3):491-6. doi: 10.1016/j.bbrc.2011.01.059.
Li J, Reed SA, Johnson SE. Hepatocyte growth factor (HGF) signals through SHP2 to regulate primary mouse myoblast proliferation. Exp Cell Res. 2009 Aug 1;315(13):2284-92. doi: 10.1016/j.yexcr.2009.04.011.
Reed SA, Johnson SE. Equine umbilical cord blood contains a population of stem cells that express Oct4 and differentiate into mesodermal and endodermal cell types. J Cell Physiol. 2008 May;215(2):329-36.
Reed SA, Ouellette SE, Liu X, Allen RE, Johnson SE. E2F5 and LEK1 translocation to the nucleus is an early event demarcating myoblast quiescence. J Cell Biochem. 2007 Aug 15;101(6):1394-408.
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Last updated: 01/19/2017 9:39:10
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University of Connecticut
Department of Animal Science
3636 Horsebarn Road Ext.
Storrs, CT 06269-4040
Phone: (860) 486-2413
Fax: (860) 486-4375