Phone: (860) 486-2480
Office: ABL, Room 302A
Lab: ABL, Room 317
Lab Phone: (860) 486-8938
After receiving her Ph.D. in 2003, Dr. Govoni pursued postdoctoral research experience in the Musculoskeletal Disease Center at the Jerry L. Pettis VA Medical Center in Loma Linda, CA. In 2008, Dr. Govoni returned to her home state of CT and is currently an Associate Professor in the Department of Animal Science.
Current research in our lab focuses on understanding growth and development at the cellular level to identify methods to improve animal health and efficiency of production. Currently there are two major focuses in the laboratory. The first is to determine the effects of poor maternal nutrition on pre- and post-natal development using a sheep model. In particular, we are working to determine the effects of under- and/or over-feeding during gestation on muscle, bone, and adipose tissue as well as the potential programming effects of maternal diet on mesenchymal stem cells in the offspring. The second focus in the laboratory is to determine the molecular mechanism involved in the attachment and invasion of S. Aureus in the bovine mammary gland using whole transcriptome analysis. In addition, we are investigating the effectiveness of plant-derived anti-microbials to prevent and or treat mastitis.
|ANSC 3194/ SAAS 294||Seminar|
|ANSC 3313/ 5613||Growth Biology & Metabolism in Domestic Livestock/ Growth and Metabolism of Domestic Animals|
|ANSC 3314W||Scientific Writing in Growth Biology|
Hoffman, M. L., Peck, K. N., Wegrzyn, J., Reed, S. A., Zinn, S., Govoni, K. Poor maternal nutrition during gestation alters the expression of genes involved in muscle development and metabolism in lambs.
Jones, A. K., Gately, R. E., McFadden, K. K., Zinn, S., Govoni, K., Reed, S. A. Transabdominal ultrasound for detection of pregnancy, fetal and placental landmarks, and fetal age before Day 45 of gestation in the sheep. 85. (5), 939-945.e1. Theriogenology.
Raja, J. S., Hoffman, M. L., Govoni, K., Zinn, S., Reed, S. A. Restricted maternal nutrition alters myogenic regulatory factor expression in satellite cells of ovine offspring., 1-4. Animal: an international journal of animal bioscience.
Harvey, B. M., Eschbach, M., Ackell, E., Kotha, S., Darre, M., Adamson, D., Ramanathan, R., Mancini, R., Govoni, KE. 2015. Effect of daily lithium chloride administration on bone quality and strength in growing broiler chickens. Poultry Science. Feb. 94. 296-301.
Reed, S. A., Raja, J. S., Hoffman, M. L., Zinn, S., Govoni, KE. 2014. Poor maternal nutrition inhibits muscle development in ovine offspring. Journal of Animal Science & Biotechnology. Sept. 1. 4.
Hoffman, ML, Rokossa, MA, Zinn, S, Hoagland, T, Govoni, KE. 2014. Poor maternal nutrition during gestation in sheep reduces circulating concentrations of insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3 in offspring. Dom Anim Endocr. Jul; 49, 39-48.
Hoffman, ML, McFadden, KK, Hoagland, T, Kazmer, G, Govoni, KE. 2014. Short communication: Expression of T-box 2 and 3 in the bovine mammary gland. J Dairy Sci. Jul; 97(7):4322-8. doi: 10.3168/jds.2013-7771.
Glynn, E, Alfredo, S-L, Zinn, S, Hoagland, T, Govoni, KE. 2013. Culture conditions for equine bone marrow mesenchymal stem cells and expression of key transcription factors during their differentiation into osteoblasts. J Anim Sci Biotechnology. Oct 29; 4(1): 40. doi: 10.1186/2049-1891-4-40.
Xing W, Govoni KE, Donahue LR, Kesavan C, Wergedal J, Long C, Bassett JH, Gogakos A, Wojcicka A, Williams GR, Mohan S. 2012. Genetic evidence that thyroid hormone is indispensable for prepubertal insulin-like growth factor-I expression and bone acquisition in mice. J Bone Miner Res. 2012 May;27(5):1067-79.
Govoni, KE. 2012. Insulin-like growth factor-I molecular pathways in osteoblasts: Potential targets for pharmacological manipulation. Curr Mol Pharmacol. 2012 Jun 1;5(2):143-52.
Ackell, ER, Sanchez-Londono, A, Zinn, SA, Hoagland, TA, and Govoni, KE. 2012. Culture conditions for equine bone marrow mesenchymal stem cells and expression of key transcription factors during their differentiation into osteoblasts. Equine Veterinary Journal. Accepted with revisions
Govoni, KE, Goodman, D, Maclure RM, Penfold, LM, and Zinn, SA. 2011. Serum concentrations of insulin-like growth factor and insulin-like growth factor binding protein-2 and -3 in eight hoofstock species. Zoo Biol. 30:275-84.
Govoni, KE, Linares, GR, Chen, ST, Pourteymoor, S, and Mohan, S. 2009. T-box 3 negatively regulates osteoblast differentiation by inhibiting expression of osterix and runx2. J Cell Biochem. 106:482-90.
Linares, GR, Xing, W, Govoni, KE, Chen, ST, and Mohan, S. 2009. Glutaredoxin 5 regulates osteoblast apoptosis by protecting against oxidative stress. Bone. 44:795-804.
Govoni, KE, Donahue LR, Marden C, Mohan S. 2008. Complex genetic regulation of bone mineral density and insulin-like growth factor-I in C57BL/6J-Chr #A/J/NaJ chromosome substitution strains. Physiol Genomics. 35:159-64. Epub 2008 Aug 5.
Govoni, KE, Wergedal, JE, Chadwick, RB, Srivistava, AK, and Mohan, S. 2008. Pre-pubertal OVX increases IGF-I expression and bone accretion in C57BL/6J mice. Am J Physiol Endocrinol Metab. 295:E1172-80. Epub 2008 Sep 23.
Govoni, KE, Wergedal, JE, Florin, L, Angel P, Baylink, DJ, and Mohan, S. 2007. Conditional Deletion of IGF-I in Collagen Type 1 alpha-2 (Col1 alpha-2) Expressing Cells Results In Postnatal Lethality and a Dramatic Reduction in Bone Accretion. Endocrinology 148:8706-15 Epub 2007 Aug 23.
Velayudhan, BT, Govoni, KE, Hoagland, TA, and Zinn, SA. 2007. Growth rate and concentrations of the somatotropic axis in beef cattle administered exogenous bovine somatotropin beginning at 200, 250 and 300 days of age. J. Anim. Sci. 85:2886-72.
Govoni, KE, Lee, SK, Chung, YS, Behringer, RR, Wergedal, JE, Baylink, DJ, and Mohan, S. 2007. Disruption of insulin-like growth factor (IGF)-I expression in type II?I collagen expressing cells reduces bone length and width in mice. Physiol. Genomics. 30:354-62 Epub 2007May 22.
Govoni, KE, Baylink, DJ, Chen, J, and Mohan, S. 2006. Disruption of four and a half LIM domain (FHL)-2 decreases bone mineral content and bone mineral density in femur and tibia bones of female mice. Calcified Tissue International 79:112-7. Epub 2006 Aug 15.
Govoni, KE, Lee, SK, Chadwick, RB, Yu, H, Kasukawa, Y, Baylink, DJ, and Mohan, S. 2006. Whole Genome Microarray Analysis of the In Vivo Effects of a Single Effective GH Dose on Gene Expression in Bones of GH-Deficient lit/lit Mice: GH regulates T-box3, a Novel Transcription Factor, Independent of IGF-I. Am. J. Physiol. Endocrinol. Metab. 291:E128-36. Epub 2006 Feb 7.
Govoni, KE, Kramer, A, Winter, E, Amaar, YG, Baylink, DJ, and Mohan, S. 2005 In Press. Regulation of insulin-like growth factor binding protein (IGFBP)-5, four and a half lim (FHL)-2, and a disintegrin and metalloprotease (ADAM)-9 expression in osteoblasts. Growth Hormone and IGF Research 16:49-56. Epub 2005 Nov 28.
Govoni, KE, Baylink, DJ, and Mohan, S. 2005. The multi-functional role of insulin-like growth factor binding proteins in bone. Pediatr. Nephrol. 20:261-268.
Govoni, KE, Hoagland, TA, and Zinn, SA. 2004. The ontogeny of the somatotropic axis in Hereford calves from birth to one year of age and its response to administration of exogenous bovine somatotropin. J. Anim. Sci. 82:1646-1655.
Govoni, KE, Hoagland, TA, and Zinn, SA. 2003. The ontogeny of the somatotropic axis in male and female Hereford calves from birth to one year of age. J. Anim. Sci. 81:2811-2817.
Govoni, KE, XC Tian, GW Kazmer, M Taneja, B Enright, AL Rivard, X Yang and SA Zinn. 2002. Age-related changes of the somatotropic axis in cloned Holstein calves. Biol. of Reprod. 66:1293-1298.
Rausch, MI, MW Tripp, KE Govoni, W Zang, WJ Weber, BA Crooker, TA Hoagland and SA Zinn. 2002. Limit feeding and somatotropin supplementation in growing beef cattle. J. Anim. Sci. 80:94-100.
Phillips, AL, C Faustman, MP Lynch, KE Govoni, TA Hoagland and SA Zinn. 2001. Effects of dietary alpha-tocopherol supplementation on color and lipid stability in pork. Meat Science 58:389-393.
Freake, HC, KE Govoni, K Guda, C Huang and SA Zinn. 2001. Actions and interactions of thyroid hormones and zinc status in growing rats. J. Nutr. 131:1135-1141.
Horseback riding, camping, hiking, running